Seasonal influenza vaccines have a low and variable efficacy that require yearly updates. Despite vaccination, there are ~1 billion influenza cases causing 290-650K deaths every year. No vaccines exist that broadly protect against pandemic influenza strains, which are a constant global threat. Harmjan Kuipers, Roland Zahn and Börries Brandenburg have developed a novel influenza vaccine concept that induces broadly reactive antibodies against a conserved region of the virus. It aims to robustly protect against seasonal and pandemic influenza strains without the need for seasonal updates, and can be stockpiled for the next influenza pandemic.